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Assay Detail

CHEMBL2038470

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiobesity activity in po dosed fasted rat assessed as reduction in TAG to DAG ratio in adipose tissue
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Adipose tissue
Confidence 1 — Organism
Curated By Autocuration

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
McCoull W, Addie MS, Birch AM, Birtles S, Buckett LK, Butlin RJ, Bowker SS, Boyd S, Chapman S, Davies RD, Donald CS, Green CP, Jenner C, Kemmitt PD, Leach AG, Moody GC, Gutierrez PM, Newcombe NJ, Nowak T, Packer MJ, Plowright AT, Revill J, Schofield P, Sheldon C, Stokes S, Turnbull AV, Wang SJ, Whalley DP, Wood JM.
Bioorg Med Chem Lett (2012) 22 : 3873 -3878
PubMed 22608962 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.52 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2036730 1 9.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2036730 IC50 = 0.3 nM 9.52