Assay Detail
Binding
CHEMBL2038586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.79 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511708 | BACCHARIN | — | 1 | 6.96 |
| CHEMBL456309 | ARTEPILLIN | — | 1 | 6.00 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 5.77 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.39 |
| CHEMBL464997 | DRUPANIN | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511708 | BACCHARIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL456309 | ARTEPILLIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL464997 | DRUPANIN | IC50 | = | 15000.0 | nM | 4.82 |