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Assay Detail

CHEMBL2038604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human U87 cells expressing wild-type p53 after 48 hrs by MTT assay
ChEMBL ↗
53
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-87MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

N⁴-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action.
Soares MA, Lessa JA, Mendes IC, Da Silva JG, Dos Santos RG, Salum LB, Daghestani H, Andricopulo AD, Day BW, Vogt A, Pesquero JL, Rocha WR, Beraldo H.
Bioorg Med Chem (2012) 20 : 3396 -3409
PubMed 22564383 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 7.85 8.85
Activity 13 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL282346 — — 1 8.85
CHEMBL2037441 — — 1 8.85
CHEMBL1867591 — — 2 8.85
CHEMBL2037445 — — 1 8.77
CHEMBL1630580 — — 1 8.77
CHEMBL2037339 — — 2 8.77
CHEMBL534423 — — 2 8.59
CHEMBL1970209 — — 1 8.59
CHEMBL1630581 — — 1 8.59
CHEMBL2037343 — — 2 8.37
CHEMBL1770165 — — 1 8.37
CHEMBL2037449 — — 1 8.37
CHEMBL2037336 — — 2 8.30
CHEMBL1771488 — — 1 8.30
CHEMBL2037442 — — 1 8.30
CHEMBL2037340 — — 2 8.21
CHEMBL2037446 — — 1 8.21
CHEMBL2037438 — — 1 8.21
CHEMBL2037444 — — 1 8.00
CHEMBL2037338 — — 2 8.00
CHEMBL2037437 — — 1 8.00
CHEMBL2037443 — — 1 7.75
CHEMBL2037436 — — 1 7.75
CHEMBL2037337 — — 2 7.75
CHEMBL1630582 — — 1 7.51
CHEMBL1725990 — — 2 7.51
CHEMBL1987055 — — 1 7.51
CHEMBL2037342 — — 2 7.23
CHEMBL2037434 — — 1 7.23
CHEMBL2037448 — — 1 7.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL282346 — IC50 = 1.4 nM 8.85
CHEMBL1867591 — IC50 = 1.4 nM 8.85
CHEMBL2037441 — IC50 = 1.4 nM 8.85
CHEMBL2037445 — IC50 = 1.698 nM 8.77
CHEMBL1630580 — IC50 = 1.698 nM 8.77
CHEMBL2037339 — IC50 = 1.7 nM 8.77
CHEMBL1630581 — IC50 = 2.6 nM 8.59
CHEMBL1970209 — IC50 = 2.6 nM 8.59
CHEMBL534423 — IC50 = 2.6 nM 8.59
CHEMBL2037343 — IC50 = 4.3 nM 8.37
CHEMBL1770165 — IC50 = 4.295 nM 8.37
CHEMBL2037449 — IC50 = 4.295 nM 8.37
CHEMBL2037442 — IC50 = 5.0 nM 8.30
CHEMBL1771488 — IC50 = 5.0 nM 8.30
CHEMBL2037336 — IC50 = 5.0 nM 8.30
CHEMBL2037340 — IC50 = 6.1 nM 8.21
CHEMBL2037438 — IC50 = 6.095 nM 8.21
CHEMBL2037446 — IC50 = 6.095 nM 8.21
CHEMBL2037444 — IC50 = 10.0 nM 8.00
CHEMBL2037338 — IC50 = 10.0 nM 8.00
CHEMBL2037437 — IC50 = 10.0 nM 8.00
CHEMBL2037443 — IC50 = 17.99 nM 7.75
CHEMBL2037436 — IC50 = 17.99 nM 7.75
CHEMBL2037337 — IC50 = 18.0 nM 7.75
CHEMBL1987055 — IC50 = 30.97 nM 7.51
CHEMBL1725990 — IC50 = 31.0 nM 7.51
CHEMBL1630582 — IC50 = 30.97 nM 7.51
CHEMBL2037342 — IC50 = 59.0 nM 7.23
CHEMBL2037434 — IC50 = 59.02 nM 7.23
CHEMBL2037448 — IC50 = 59.02 nM 7.23
CHEMBL2037344 — IC50 = 69.0 nM 7.16
CHEMBL2037439 — IC50 = 69.02 nM 7.16
CHEMBL2037450 — IC50 = 69.02 nM 7.16
CHEMBL2037341 — IC50 = 84.0 nM 7.08
CHEMBL2037433 — IC50 = 83.95 nM 7.08
CHEMBL2037447 — IC50 = 83.95 nM 7.08
CHEMBL2037440 — IC50 = 159.96 nM 6.80
CHEMBL2037435 — IC50 = 160.0 nM 6.80
CHEMBL2037451 — IC50 = 159.96 nM 6.80
CHEMBL44657 ETOPOSIDE IC50 = 620.0 nM 6.21
CHEMBL1867591 — Activity - — -
CHEMBL2037336 — Activity - — -
CHEMBL2037337 — Activity - — -
CHEMBL2037338 — Activity - — -
CHEMBL534423 — Activity - — -
CHEMBL1725990 — Activity - — -
CHEMBL2037339 — Activity - — -
CHEMBL2037340 — Activity - — -
CHEMBL2037341 — Activity - — -
CHEMBL2037342 — Activity - — -