Assay Detail
Functional
CHEMBL2038698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in rat polymorphonuclear leukocytes assessed as inhibition of LPS-stimulated nitric oxide production after 20 mins by Griess method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive quassinoids from the seeds of Brucea javanica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.55 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.64 |
| CHEMBL140809 | BRUCEINE B | — | 1 | 5.72 |
| CHEMBL2037038 | BRUCEINE E | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL140809 | BRUCEINE B | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2037038 | BRUCEINE E | IC50 | = | 5000.0 | nM | 5.30 |