Assay Detail
Functional
CHEMBL2038858
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Antiproliferative activity against mouse BA/F3 cells expressing Tel-KDR
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.03 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2037215 | — | — | 1 | 6.70 |
| CHEMBL2037221 | — | — | 1 | 6.64 |
| CHEMBL2037208 | — | — | 1 | 6.30 |
| CHEMBL2037209 | — | — | 1 | 6.30 |
| CHEMBL2037211 | — | — | 1 | 6.30 |
| CHEMBL2037224 | — | — | 1 | 6.28 |
| CHEMBL2037194 | — | — | 1 | 6.22 |
| CHEMBL2037218 | — | — | 1 | 6.22 |
| CHEMBL2037213 | — | — | 1 | 6.21 |
| CHEMBL2037212 | — | — | 1 | 6.16 |
| CHEMBL2037193 | — | — | 1 | 6.00 |
| CHEMBL2037222 | — | — | 1 | 5.89 |
| CHEMBL2037220 | — | — | 1 | 5.82 |
| CHEMBL2037217 | — | — | 1 | 5.66 |
| CHEMBL2037210 | — | — | 1 | 5.55 |
| CHEMBL2037226 | — | — | 1 | 5.52 |
| CHEMBL2037225 | — | — | 1 | 5.48 |
| CHEMBL2037214 | — | — | 1 | 5.31 |
| CHEMBL2037216 | — | — | 1 | - |
| CHEMBL2037219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2037215 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2037221 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2037208 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2037209 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2037211 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2037224 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2037194 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2037218 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2037213 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2037212 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2037193 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2037222 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2037220 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2037217 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2037210 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2037226 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2037225 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2037214 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2037216 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2037219 | — | IC50 | > | 10000.0 | nM | - |