Assay Detail
Binding
CHEMBL2038873
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Inhibition of Tel-fused FLT3 in mouse BA/F3 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL2034796) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.30 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2037224 | — | — | 1 | 5.68 |
| CHEMBL2037209 | — | — | 1 | 5.33 |
| CHEMBL2037226 | — | — | 1 | 5.29 |
| CHEMBL2037220 | — | — | 1 | 5.26 |
| CHEMBL2037211 | — | — | 1 | 5.19 |
| CHEMBL2037208 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2037224 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2037209 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2037226 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2037220 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2037211 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2037208 | — | IC50 | = | 9400.0 | nM | 5.03 |