Assay Detail
Binding
CHEMBL2038877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11β-hydroxysteroid dehydrogenases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | 9.40 |
| CHEMBL2035569 | CALONCOBIC ACID B | — | 1 | 6.40 |
| CHEMBL2035568 | CALONCOBIC ACID A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2035569 | CALONCOBIC ACID B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2035568 | CALONCOBIC ACID A | IC50 | > | 100000.0 | nM | - |