Assay Detail
Binding
CHEMBL2038985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.08 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2037208 | — | — | 1 | 8.70 |
| CHEMBL2037209 | — | — | 1 | 7.00 |
| CHEMBL2037224 | — | — | 1 | 6.92 |
| CHEMBL2037211 | — | — | 1 | 6.70 |
| CHEMBL2037226 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2037208 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2037209 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2037224 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2037211 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2037226 | — | IC50 | = | 870.0 | nM | 6.06 |