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Assay Detail

CHEMBL2038986

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Bioactive quassinoids from the seeds of Brucea javanica.
Liu JH, Zhao N, Zhang GJ, Yu SS, Wu LJ, Qu J, Ma SG, Chen XG, Zhang TQ, Bai J, Chen H, Fang ZF, Zhao F, Tang WB.
J Nat Prod (2012) 75 : 683 -688
PubMed 22506620 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.16 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 8.36
CHEMBL140809 BRUCEINE B 1 6.09
CHEMBL477693 BRUCEINE D 1 5.92
CHEMBL2037039 BRUCEINE H 1 5.55
CHEMBL2037038 BRUCEINE E 1 5.54
CHEMBL2037040 DEHYDROBRUSATOL 1 5.48
CHEMBL2037032 BRUCEANIC ACID E 1 -
CHEMBL2037033 BRUCEANIC ACID F 1 -
CHEMBL2037034 BRUCEANIC ACID E METHYL ESTER 1 -
CHEMBL2037035 JAVANIC ACID A 1 -
CHEMBL2448519 1 -
CHEMBL2037037 JAVANICOLIDE H 1 -
CHEMBL504960 BRUCEOSIDE A 1 -
CHEMBL505100 BRUCEANTINOSIDE A 1 -
CHEMBL2037041 JAVANICOLIDE E 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 4.4 nM 8.36
CHEMBL140809 BRUCEINE B IC50 = 810.0 nM 6.09
CHEMBL477693 BRUCEINE D IC50 = 1200.0 nM 5.92
CHEMBL2037039 BRUCEINE H IC50 = 2800.0 nM 5.55
CHEMBL2037038 BRUCEINE E IC50 = 2900.0 nM 5.54
CHEMBL2037040 DEHYDROBRUSATOL IC50 = 3300.0 nM 5.48
CHEMBL2037032 BRUCEANIC ACID E IC50 > 10000.0 nM -
CHEMBL2037033 BRUCEANIC ACID F IC50 > 10000.0 nM -
CHEMBL2037034 BRUCEANIC ACID E METHYL ESTER IC50 > 10000.0 nM -
CHEMBL2037035 JAVANIC ACID A IC50 > 10000.0 nM -
CHEMBL2448519 IC50 > 10000.0 nM -
CHEMBL2037037 JAVANICOLIDE H IC50 > 10000.0 nM -
CHEMBL504960 BRUCEOSIDE A IC50 > 10000.0 nM -
CHEMBL505100 BRUCEANTINOSIDE A IC50 > 10000.0 nM -
CHEMBL2037041 JAVANICOLIDE E IC50 > 10000.0 nM -