Assay Detail
Binding
CHEMBL2039155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measured after 42 secs by TBA-based fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.89 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035651 | — | — | 1 | 8.63 |
| CHEMBL2035653 | — | — | 1 | 8.08 |
| CHEMBL2035652 | — | — | 1 | 6.56 |
| CHEMBL2035654 | — | — | 1 | 6.18 |
| CHEMBL2035656 | — | — | 1 | 6.07 |
| CHEMBL2035655 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035651 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL2035653 | — | IC50 | = | 8.26 | nM | 8.08 |
| CHEMBL2035652 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL2035654 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL2035656 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL2035655 | — | IC50 | = | 1480.0 | nM | 5.83 |