Assay Detail
Binding
CHEMBL2039587
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Inhibition of TrxR in human U87MG cells after 12 hrs by insulin-reducing method
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 2 | 5.50 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035489 | — | — | 1 | 5.70 |
| CHEMBL2035460 | ETHASELEN | 1.0 | 2 | 5.30 |
| CHEMBL2035470 | — | — | 1 | - |
| CHEMBL2035482 | — | — | 1 | - |
| CHEMBL2035484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035489 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2035460 | ETHASELEN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2035460 | ETHASELEN | Inhibition | - | % | - | |
| CHEMBL2035470 | — | Inhibition | - | % | - | |
| CHEMBL2035482 | — | Inhibition | - | % | - | |
| CHEMBL2035484 | — | Inhibition | - | % | - |