Assay Detail
Functional
CHEMBL2039796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 7.89 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035973 | — | — | 1 | 8.34 |
| CHEMBL2035964 | — | — | 1 | 8.31 |
| CHEMBL2035968 | — | — | 1 | 8.26 |
| CHEMBL2034992 | — | — | 1 | 8.25 |
| CHEMBL2035967 | — | — | 1 | 8.24 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL2035975 | — | — | 1 | 8.22 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.18 |
| CHEMBL2035974 | — | — | 1 | 8.16 |
| CHEMBL2035971 | — | — | 1 | 8.14 |
| CHEMBL2035970 | — | — | 1 | 8.10 |
| CHEMBL2035978 | — | — | 1 | 8.06 |
| CHEMBL2035969 | — | — | 1 | 7.99 |
| CHEMBL2035979 | — | — | 1 | 7.97 |
| CHEMBL2035965 | — | — | 1 | 7.94 |
| CHEMBL2035980 | — | — | 1 | 7.92 |
| CHEMBL2035976 | — | — | 1 | 7.88 |
| CHEMBL2035977 | — | — | 1 | 7.83 |
| CHEMBL2035972 | — | — | 1 | 7.80 |
| CHEMBL2035966 | — | — | 1 | 7.69 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 7.46 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.70 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035973 | — | EC50 | = | 4.61 | nM | 8.34 |
| CHEMBL2035964 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2035968 | — | EC50 | = | 5.55 | nM | 8.26 |
| CHEMBL2034992 | — | EC50 | = | 5.66 | nM | 8.25 |
| CHEMBL2035967 | — | EC50 | = | 5.75 | nM | 8.24 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2035975 | — | EC50 | = | 6.06 | nM | 8.22 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 6.57 | nM | 8.18 |
| CHEMBL2035974 | — | EC50 | = | 6.99 | nM | 8.16 |
| CHEMBL2035971 | — | EC50 | = | 7.25 | nM | 8.14 |
| CHEMBL2035970 | — | EC50 | = | 7.87 | nM | 8.10 |
| CHEMBL2035978 | — | EC50 | = | 8.64 | nM | 8.06 |
| CHEMBL2035969 | — | EC50 | = | 10.25 | nM | 7.99 |
| CHEMBL2035979 | — | EC50 | = | 10.62 | nM | 7.97 |
| CHEMBL2035965 | — | EC50 | = | 11.55 | nM | 7.94 |
| CHEMBL2035980 | — | EC50 | = | 11.9 | nM | 7.92 |
| CHEMBL2035976 | — | EC50 | = | 13.32 | nM | 7.88 |
| CHEMBL2035977 | — | EC50 | = | 14.71 | nM | 7.83 |
| CHEMBL2035972 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2035966 | — | EC50 | = | 20.43 | nM | 7.69 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 35.01 | nM | 7.46 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 200.4 | nM | 6.70 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 1394.28 | nM | 5.86 |