Assay Detail
Functional
CHEMBL2040052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimigraine activity in iv dosed rhesus monkey assessed as inhibition of capsaicin-induced dermal vasodilation administered 5 mins post capsaicin-challenge measured after 20 mins by laser doppler scanning
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca mulatta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 9.10 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910936 | MK3207 | 2.0 | 1 | 9.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910936 | MK3207 | EC50 | = | 0.8 | nM | 9.10 |