Assay Detail
Functional
CHEMBL2040192
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Cytotoxicity against human p53-deficient HCT116 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.35 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035907 | — | — | 1 | 5.58 |
| CHEMBL2035916 | — | — | 1 | 5.55 |
| CHEMBL2035915 | — | — | 1 | 5.48 |
| CHEMBL2035906 | — | — | 1 | 5.39 |
| CHEMBL2035926 | — | — | 1 | 5.37 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | — | 1 | 5.21 |
| CHEMBL2035911 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035907 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2035916 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2035915 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2035906 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2035926 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2035911 | — | IC50 | = | 13700.0 | nM | 4.86 |