Assay Detail

CHEMBL2044558

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Functional

Cytotoxicity against CD70 deficient human L540cy cells expressing CD30 after 96 hrs

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	L540cy
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents.

Jeffrey SC, De Brabander J, Miyamoto J, Senter PD.
ACS Med Chem Lett (2010) 1 : 277 -280
PubMed 24900208 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.15	9.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2041750	IRCINIASTATIN A	—	1	9.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2041750	IRCINIASTATIN A	IC50	=	0.7	nM	9.15