Assay Detail
Functional
CHEMBL2044697
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Antiviral activity against Dengue virus 2 infected in BHK-D2RepT replicon systems assessed as inhibition of viral replication after 24 hrs by luciferase reporter gene assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 7.12 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042321 | — | — | 1 | 8.55 |
| CHEMBL2042322 | — | — | 1 | 8.13 |
| CHEMBL2042320 | — | — | 1 | 8.10 |
| CHEMBL2042324 | — | — | 1 | 8.04 |
| CHEMBL343286 | — | — | 1 | 7.54 |
| CHEMBL341590 | — | — | 1 | 7.44 |
| CHEMBL343382 | — | — | 1 | 7.43 |
| CHEMBL342595 | — | — | 1 | 7.41 |
| CHEMBL2042316 | — | — | 1 | 7.22 |
| CHEMBL402274 | — | — | 1 | 7.10 |
| CHEMBL2042323 | — | — | 1 | 6.89 |
| CHEMBL343543 | — | — | 1 | 6.82 |
| CHEMBL2042325 | — | — | 1 | 6.82 |
| CHEMBL2042319 | — | — | 1 | 6.75 |
| CHEMBL2042326 | — | — | 1 | 6.05 |
| CHEMBL336468 | — | — | 1 | 5.48 |
| CHEMBL2042315 | — | — | 1 | 5.27 |
| CHEMBL2042327 | — | — | 1 | - |
| CHEMBL2042318 | — | — | 1 | - |
| CHEMBL2042317 | — | — | 1 | - |
| CHEMBL2042314 | — | — | 1 | - |
| CHEMBL2042313 | — | — | 1 | - |
| CHEMBL342269 | — | — | 1 | - |
| CHEMBL268354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042321 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2042322 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL2042320 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL2042324 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL343286 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL341590 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL343382 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL342595 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2042316 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL402274 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2042323 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL343543 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2042325 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2042319 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2042326 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL336468 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2042315 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2042327 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2042318 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2042317 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2042314 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2042313 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL342269 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL268354 | — | EC50 | > | 10000.0 | nM | - |