Assay Detail

CHEMBL2044749

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Growth inhibition of ALK-positive human SUP-M2 cells by MTS assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SUP-M2
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity.

Ott GR, Tripathy R, Cheng M, McHugh R, Anzalone AV, Underiner TL, Curry MA, Quail MR, Lu L, Wan W, Angeles TS, Albom MS, Aimone LD, Ator MA, Ruggeri BA, Dorsey BD.
ACS Med Chem Lett (2010) 1 : 493 -498
PubMed 24900237 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2042829	—	—	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2042829	—	EC50	=	200.0	nM	6.70