Assay Detail
Functional
CHEMBL2044970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 3B infected in human HeLa cells assessed as inhibition of viral replication after 48 hrs by MAGI assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent CXCR4 antagonists containing amidine type Peptide bond isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.12 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042117 | — | — | 1 | 9.21 |
| CHEMBL2042118 | — | — | 1 | 9.00 |
| CHEMBL2042232 | — | — | 1 | 8.92 |
| CHEMBL2042119 | — | — | 1 | 8.70 |
| CHEMBL2042120 | — | — | 1 | 8.20 |
| CHEMBL1949730 | — | — | 1 | 8.12 |
| CHEMBL436283 | — | — | 1 | 7.68 |
| CHEMBL2042234 | — | — | 1 | 6.62 |
| CHEMBL2042233 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042117 | — | EC50 | = | 0.61 | nM | 9.21 |
| CHEMBL2042118 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2042232 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2042119 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2042120 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1949730 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL436283 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2042234 | — | EC50 | = | 238.0 | nM | 6.62 |
| CHEMBL2042233 | — | EC50 | = | 258.0 | nM | 6.59 |