Assay Detail
Binding
CHEMBL2045461
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Inhibition of porcine brain GSK3alpha/beta using GS1 as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.42 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041917 | — | — | 1 | 7.39 |
| CHEMBL2041915 | — | — | 1 | 7.35 |
| CHEMBL2041919 | — | — | 1 | 6.77 |
| CHEMBL239698 | — | — | 1 | 6.38 |
| CHEMBL2041914 | — | — | 1 | 6.31 |
| CHEMBL393545 | — | — | 1 | 6.24 |
| CHEMBL2041916 | — | — | 1 | 6.16 |
| CHEMBL2041918 | — | — | 1 | 6.05 |
| CHEMBL2041749 | — | — | 1 | 5.77 |
| CHEMBL2041912 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041917 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2041915 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2041919 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL239698 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2041914 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL393545 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2041916 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2041918 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2041749 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2041912 | — | IC50 | = | 1700.0 | nM | 5.77 |