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Assay Detail

CHEMBL2045824

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human CA6 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 6 (CHEMBL3025)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: vidalol B.
Balaydın HT, Şentürk M, Göksu S, Menzek A.
Eur J Med Chem (2012) 54 : 423 -428
PubMed 22687439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 4.73 5.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL477748 VIDALOL B 1 5.47
CHEMBL37537 PROTOCATECHUIC ACID 1 5.33
CHEMBL2042369 1 4.95
CHEMBL253691 1 4.86
CHEMBL118903 VERATRIC ACID 1 4.61
CHEMBL2042368 1 4.55
CHEMBL506166 TETRABROMOCATECHOL 1 4.54
CHEMBL2016670 1 4.53
CHEMBL2042370 1 4.45
CHEMBL2042371 1 4.42
CHEMBL2040866 1 4.34
CHEMBL2016664 1 -
CHEMBL278024 ANISOLE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL477748 VIDALOL B Ki = 3410.0 nM 5.47
CHEMBL37537 PROTOCATECHUIC ACID Ki = 4720.0 nM 5.33
CHEMBL2042369 Ki = 11143.0 nM 4.95
CHEMBL253691 Ki = 13692.0 nM 4.86
CHEMBL118903 VERATRIC ACID Ki = 24420.0 nM 4.61
CHEMBL2042368 Ki = 28170.0 nM 4.55
CHEMBL506166 TETRABROMOCATECHOL Ki = 29138.0 nM 4.54
CHEMBL2016670 Ki = 29670.0 nM 4.53
CHEMBL2042370 Ki = 35450.0 nM 4.45
CHEMBL2042371 Ki = 38190.0 nM 4.42
CHEMBL2040866 Ki = 45360.0 nM 4.34
CHEMBL2016664 Ki = 382473.0 nM -
CHEMBL278024 ANISOLE Ki = 234700.0 nM -