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Assay Detail

CHEMBL2045873

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human U373 cells after 72 hrs by MTT assay
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-373MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.
Goffin E, Lamoral-Theys D, Tajeddine N, de Tullio P, Mondin L, Lefranc F, Gailly P, Rogister B, Kiss R, Pirotte B.
Eur J Med Chem (2012) 54 : 834 -844
PubMed 22809560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 4.69 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL593820 — — 1 5.52
CHEMBL608379 — — 1 5.52
CHEMBL595242 — — 1 5.52
CHEMBL609853 — — 1 5.40
CHEMBL596383 — — 1 5.22
CHEMBL593579 — — 1 5.22
CHEMBL610773 — — 1 5.16
CHEMBL447283 — — 1 5.16
CHEMBL2041939 — — 1 5.10
CHEMBL497954 — — 1 5.10
CHEMBL2041938 — — 1 5.10
CHEMBL593296 — — 1 5.05
CHEMBL595765 — — 1 5.00
CHEMBL596384 — — 1 4.96
CHEMBL367287 — — 1 4.96
CHEMBL211146 — — 1 4.77
CHEMBL209857 — — 1 4.72
CHEMBL213706 — — 1 4.72
CHEMBL377467 — — 1 4.68
CHEMBL611936 — — 1 4.66
CHEMBL2041936 — — 1 4.66
CHEMBL468570 — — 1 4.66
CHEMBL373788 — — 1 4.62
CHEMBL425784 — — 1 4.60
CHEMBL2041934 — — 1 4.57
CHEMBL177950 — — 1 4.57
CHEMBL176290 — — 1 4.57
CHEMBL176381 — — 1 4.54
CHEMBL595929 — — 1 4.52
CHEMBL2041935 — — 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL593820 — IC50 = 3000.0 nM 5.52
CHEMBL595242 — IC50 = 3000.0 nM 5.52
CHEMBL608379 — IC50 = 3000.0 nM 5.52
CHEMBL609853 — IC50 = 4000.0 nM 5.40
CHEMBL596383 — IC50 = 6000.0 nM 5.22
CHEMBL593579 — IC50 = 6000.0 nM 5.22
CHEMBL610773 — IC50 = 7000.0 nM 5.16
CHEMBL447283 — IC50 = 7000.0 nM 5.16
CHEMBL2041939 — IC50 = 8000.0 nM 5.10
CHEMBL497954 — IC50 = 8000.0 nM 5.10
CHEMBL2041938 — IC50 = 8000.0 nM 5.10
CHEMBL593296 — IC50 = 9000.0 nM 5.05
CHEMBL595765 — IC50 = 10000.0 nM 5.00
CHEMBL367287 — IC50 = 11000.0 nM 4.96
CHEMBL596384 — IC50 = 11000.0 nM 4.96
CHEMBL211146 — IC50 = 17000.0 nM 4.77
CHEMBL209857 — IC50 = 19000.0 nM 4.72
CHEMBL213706 — IC50 = 19000.0 nM 4.72
CHEMBL377467 — IC50 = 21000.0 nM 4.68
CHEMBL611936 — IC50 = 22000.0 nM 4.66
CHEMBL2041936 — IC50 = 22000.0 nM 4.66
CHEMBL468570 — IC50 = 22000.0 nM 4.66
CHEMBL373788 — IC50 = 24000.0 nM 4.62
CHEMBL425784 — IC50 = 25000.0 nM 4.60
CHEMBL176290 — IC50 = 27000.0 nM 4.57
CHEMBL177950 — IC50 = 27000.0 nM 4.57
CHEMBL2041934 — IC50 = 27000.0 nM 4.57
CHEMBL176381 — IC50 = 29000.0 nM 4.54
CHEMBL595929 — IC50 = 30000.0 nM 4.52
CHEMBL2041935 — IC50 = 32000.0 nM 4.50
CHEMBL2041937 — IC50 = 32000.0 nM 4.50
CHEMBL496089 — IC50 = 34000.0 nM 4.47
CHEMBL378033 — IC50 = 39000.0 nM 4.41
CHEMBL467766 — IC50 = 40000.0 nM 4.40
CHEMBL265129 — IC50 = 40000.0 nM 4.40
CHEMBL468384 — IC50 = 46000.0 nM 4.34
CHEMBL367333 — IC50 = 57000.0 nM 4.24
CHEMBL367494 — IC50 = 62000.0 nM 4.21
CHEMBL360709 — IC50 = 64000.0 nM 4.19
CHEMBL513524 — IC50 = 66000.0 nM 4.18
CHEMBL175918 — IC50 = 66000.0 nM 4.18
CHEMBL379715 — IC50 = 68000.0 nM 4.17
CHEMBL209643 — IC50 = 69000.0 nM 4.16
CHEMBL177121 — IC50 = 96000.0 nM 4.02
CHEMBL369730 — IC50 = 96000.0 nM 4.02
CHEMBL325931 — IC50 > 100000.0 nM -
CHEMBL1159 PINACIDIL ANHYDROUS IC50 > 100000.0 nM -
CHEMBL472 GLYBURIDE IC50 > 100000.0 nM -
CHEMBL369451 — IC50 > 100000.0 nM -
CHEMBL191182 — IC50 > 100000.0 nM -