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Assay Detail

CHEMBL2045875

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Functional
Growth inhibition of human Hs683 cells after 72 hrs by MTT assay
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Hs 683
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.
Goffin E, Lamoral-Theys D, Tajeddine N, de Tullio P, Mondin L, Lefranc F, Gailly P, Rogister B, Kiss R, Pirotte B.
Eur J Med Chem (2012) 54 : 834 -844
PubMed 22809560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 4.76 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL608379 — — 1 5.70
CHEMBL593296 — — 1 5.52
CHEMBL609853 — — 1 5.52
CHEMBL593820 — — 1 5.52
CHEMBL595242 — — 1 5.52
CHEMBL596383 — — 1 5.40
CHEMBL610773 — — 1 5.22
CHEMBL2041938 — — 1 5.22
CHEMBL595765 — — 1 5.22
CHEMBL593579 — — 1 5.22
CHEMBL2041939 — — 1 5.16
CHEMBL497954 — — 1 5.10
CHEMBL447283 — — 1 5.05
CHEMBL596384 — — 1 4.85
CHEMBL2041936 — — 1 4.82
CHEMBL611936 — — 1 4.82
CHEMBL377467 — — 1 4.77
CHEMBL367287 — — 1 4.72
CHEMBL209857 — — 1 4.66
CHEMBL496089 — — 1 4.66
CHEMBL213706 — — 1 4.66
CHEMBL2041937 — — 1 4.64
CHEMBL425784 — — 1 4.62
CHEMBL211146 — — 1 4.60
CHEMBL177950 — — 1 4.60
CHEMBL373788 — — 1 4.60
CHEMBL2041934 — — 1 4.57
CHEMBL467766 — — 1 4.54
CHEMBL265129 — — 1 4.54
CHEMBL468384 — — 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL608379 — IC50 = 2000.0 nM 5.70
CHEMBL593296 — IC50 = 3000.0 nM 5.52
CHEMBL595242 — IC50 = 3000.0 nM 5.52
CHEMBL609853 — IC50 = 3000.0 nM 5.52
CHEMBL593820 — IC50 = 3000.0 nM 5.52
CHEMBL596383 — IC50 = 4000.0 nM 5.40
CHEMBL610773 — IC50 = 6000.0 nM 5.22
CHEMBL2041938 — IC50 = 6000.0 nM 5.22
CHEMBL595765 — IC50 = 6000.0 nM 5.22
CHEMBL593579 — IC50 = 6000.0 nM 5.22
CHEMBL2041939 — IC50 = 7000.0 nM 5.16
CHEMBL497954 — IC50 = 8000.0 nM 5.10
CHEMBL447283 — IC50 = 9000.0 nM 5.05
CHEMBL596384 — IC50 = 14000.0 nM 4.85
CHEMBL611936 — IC50 = 15000.0 nM 4.82
CHEMBL2041936 — IC50 = 15000.0 nM 4.82
CHEMBL377467 — IC50 = 17000.0 nM 4.77
CHEMBL367287 — IC50 = 19000.0 nM 4.72
CHEMBL209857 — IC50 = 22000.0 nM 4.66
CHEMBL496089 — IC50 = 22000.0 nM 4.66
CHEMBL213706 — IC50 = 22000.0 nM 4.66
CHEMBL2041937 — IC50 = 23000.0 nM 4.64
CHEMBL425784 — IC50 = 24000.0 nM 4.62
CHEMBL373788 — IC50 = 25000.0 nM 4.60
CHEMBL177950 — IC50 = 25000.0 nM 4.60
CHEMBL211146 — IC50 = 25000.0 nM 4.60
CHEMBL2041934 — IC50 = 27000.0 nM 4.57
CHEMBL467766 — IC50 = 29000.0 nM 4.54
CHEMBL265129 — IC50 = 29000.0 nM 4.54
CHEMBL468384 — IC50 = 32000.0 nM 4.50
CHEMBL595929 — IC50 = 33000.0 nM 4.48
CHEMBL379715 — IC50 = 33000.0 nM 4.48
CHEMBL367333 — IC50 = 34000.0 nM 4.47
CHEMBL176381 — IC50 = 34000.0 nM 4.47
CHEMBL378033 — IC50 = 38000.0 nM 4.42
CHEMBL176290 — IC50 = 38000.0 nM 4.42
CHEMBL468570 — IC50 = 40000.0 nM 4.40
CHEMBL2041935 — IC50 = 41000.0 nM 4.39
CHEMBL360709 — IC50 = 43000.0 nM 4.37
CHEMBL175918 — IC50 = 47000.0 nM 4.33
CHEMBL209643 — IC50 = 61000.0 nM 4.21
CHEMBL369730 — IC50 = 72000.0 nM 4.14
CHEMBL513524 — IC50 = 81000.0 nM 4.09
CHEMBL367494 — IC50 = 85000.0 nM 4.07
CHEMBL369451 — IC50 - — -
CHEMBL177121 — IC50 > 100000.0 nM -
CHEMBL810 TEMOZOLOMIDE IC50 = 956000.0 nM -
CHEMBL354907 — IC50 - — -
CHEMBL175672 — IC50 - — -