Assay Detail
Functional
CHEMBL2045979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 SF33 infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.20 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041783 | — | — | 1 | 8.70 |
| CHEMBL2041780 | — | — | 1 | 8.22 |
| CHEMBL2041784 | — | — | 1 | 8.22 |
| CHEMBL2041788 | — | — | 1 | 8.05 |
| CHEMBL2041792 | — | — | 1 | 7.85 |
| CHEMBL436546 | — | — | 1 | 7.66 |
| CHEMBL2041782 | — | — | 1 | 7.35 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.17 |
| CHEMBL2041791 | — | — | 1 | 6.46 |
| CHEMBL2041781 | — | — | 1 | 6.27 |
| CHEMBL2041789 | — | — | 1 | 6.21 |
| CHEMBL2041787 | — | — | 1 | 5.76 |
| CHEMBL2041785 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041783 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2041780 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2041784 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2041788 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2041792 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL436546 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2041782 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2041791 | — | EC50 | = | 345.0 | nM | 6.46 |
| CHEMBL2041781 | — | EC50 | = | 537.0 | nM | 6.27 |
| CHEMBL2041789 | — | EC50 | = | 614.0 | nM | 6.21 |
| CHEMBL2041787 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL2041785 | — | EC50 | = | 2071.0 | nM | 5.68 |