Assay Detail

CHEMBL2049355

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Functional

Cytotoxicity against Her2-overexpressing human BT474 cells after 72 hrs by MTT assay

ChEMBL ↗

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Target

BT-474 (CHEMBL614529) ↗

Open DB target context

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BT-474 (CHEMBL614529) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target BT-474

CHEMBL614529

Anchored from Assay target.

Protein identity BT-474

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	BT-474
Confidence	1 — Organism
Curated By	Autocuration

Target

BT-474 (CHEMBL614529) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Plumbagin induces apoptosis in Her2-overexpressing breast cancer cells through the mitochondrial-mediated pathway.

Kawiak A, Zawacka-Pankau J, Lojkowska E.
J Nat Prod (2012) 75 : 747 -751
PubMed 22512718 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.10	6.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL295316	PLUMBAGIN	1.0	1	6.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL295316	PLUMBAGIN	IC50	=	800.0	nM	6.10