Assay Detail
Functional
CHEMBL2049375
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Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.49 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.03 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | 6.22 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 6.00 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | IC50 | = | 1900.0 | nM | 5.72 |