Assay Detail
Functional
CHEMBL2049381
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Cytotoxicity against human WM9 cells after 72 hrs by XTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WM9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.73 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.82 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | — | 1 | 5.57 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | 4.90 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 23500.0 | nM | 4.63 |