Assay Detail
Functional
CHEMBL2049892
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Cytotoxicity against human HCT116 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.18 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047959 | — | — | 1 | 7.96 |
| CHEMBL2048081 | — | — | 1 | 7.82 |
| CHEMBL2047961 | — | — | 1 | 7.82 |
| CHEMBL2047962 | — | — | 1 | 7.77 |
| CHEMBL2047968 | — | — | 1 | 7.66 |
| CHEMBL2047963 | — | — | 1 | 7.66 |
| CHEMBL2047960 | — | — | 1 | 7.66 |
| CHEMBL2047964 | — | — | 1 | 7.64 |
| CHEMBL2047966 | — | — | 1 | 7.57 |
| CHEMBL2047955 | — | — | 1 | 7.48 |
| CHEMBL2047972 | — | — | 1 | 7.44 |
| CHEMBL2047971 | — | — | 1 | 7.31 |
| CHEMBL2048082 | — | — | 1 | 7.30 |
| CHEMBL2047970 | — | — | 1 | 7.30 |
| CHEMBL2047965 | — | — | 1 | 7.29 |
| CHEMBL2048078 | — | — | 1 | 7.29 |
| CHEMBL2047969 | — | — | 1 | 7.24 |
| CHEMBL2048080 | — | — | 1 | 7.23 |
| CHEMBL2047967 | — | — | 1 | 7.18 |
| CHEMBL2047956 | — | — | 1 | 7.16 |
| CHEMBL2048079 | — | — | 1 | 7.13 |
| CHEMBL2047958 | — | — | 1 | 7.06 |
| CHEMBL2047943 | — | — | 1 | 7.00 |
| CHEMBL2047950 | — | — | 1 | 6.89 |
| CHEMBL2047957 | — | — | 1 | 6.28 |
| CHEMBL2047952 | — | — | 1 | 6.27 |
| CHEMBL2047951 | — | — | 1 | 6.16 |
| CHEMBL2047948 | — | — | 1 | 6.10 |
| CHEMBL2047946 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047959 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2048081 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2047961 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2047962 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2047968 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2047963 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2047960 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2047964 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2047966 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2047955 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2047972 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2047971 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2048082 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2047970 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2047965 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2048078 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2047969 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2048080 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2047967 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2047956 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2048079 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2047958 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2047943 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2047950 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2047957 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2047952 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2047951 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2047948 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2047946 | — | IC50 | = | 3200.0 | nM | 5.50 |