Assay Detail
Functional
CHEMBL2049983
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Cytotoxicity against human GTL16 cells expressing MET assessed as inhibition of anchorage-independent cell growth treated every 3 days for 2 weeks by MTT assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GTL 16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.70 | 6.10 |
| GI | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927770 | — | — | 1 | 6.10 |
| CHEMBL1927771 | — | — | 1 | 5.92 |
| CHEMBL2046801 | — | — | 2 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927770 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1927771 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL2046801 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2046801 | — | GI | - | — | - |