Assay Detail
Binding
CHEMBL2050358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells after 90 mins by liquid scintillation counting in the presence of 0.2%BSA
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.66 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047164 | — | — | 1 | 7.25 |
| CHEMBL2047170 | — | — | 1 | 7.23 |
| CHEMBL2047161 | — | — | 1 | 7.18 |
| CHEMBL2047151 | — | — | 1 | 7.08 |
| CHEMBL2047169 | — | — | 1 | 6.96 |
| CHEMBL2047152 | — | — | 1 | 6.96 |
| CHEMBL2047166 | — | — | 1 | 6.92 |
| CHEMBL2047159 | — | — | 1 | 6.85 |
| CHEMBL2047155 | — | — | 1 | 6.77 |
| CHEMBL2047160 | — | — | 1 | 6.77 |
| CHEMBL2047158 | — | — | 1 | 6.77 |
| CHEMBL2047157 | — | — | 1 | 6.77 |
| CHEMBL2047163 | — | — | 1 | 6.72 |
| CHEMBL2047168 | — | — | 1 | 6.70 |
| CHEMBL2047154 | — | — | 1 | 6.68 |
| CHEMBL2047149 | — | — | 1 | 6.62 |
| CHEMBL2047167 | — | — | 1 | 6.57 |
| CHEMBL2022577 | — | — | 1 | 6.52 |
| CHEMBL2047162 | — | — | 1 | 6.44 |
| CHEMBL2047165 | — | — | 1 | 6.40 |
| CHEMBL2047156 | — | — | 1 | 6.29 |
| CHEMBL2047153 | — | — | 1 | 5.66 |
| CHEMBL2047150 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047164 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL2047170 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2047161 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2047151 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL2047169 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2047152 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2047166 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2047159 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2047155 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2047160 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2047158 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2047157 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2047163 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2047168 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2047154 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2047149 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2047167 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2022577 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2047162 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL2047165 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2047156 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL2047153 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL2047150 | — | Ki | = | 7400.0 | nM | 5.13 |