Assay Detail
Binding
CHEMBL2050449
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Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate after 30 mins by spectrophotometric analysis
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.83 | 5.01 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233375 | — | — | 2 | 5.01 |
| CHEMBL87706 | — | — | 2 | 4.87 |
| CHEMBL287556 | KOJIC ACID | — | 2 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233375 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL87706 | — | IC50 | = | 13360.0 | nM | 4.87 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 24720.0 | nM | 4.61 |
| CHEMBL87706 | — | Inhibition | - | % | - | |
| CHEMBL233375 | — | Inhibition | - | % | - | |
| CHEMBL287556 | KOJIC ACID | Inhibition | - | % | - |