Assay Detail
Functional
CHEMBL2050754
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Growth inhibition of human DLD1 cells after 48 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.20 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047849 | — | — | 1 | 8.62 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.48 |
| CHEMBL2047848 | — | — | 1 | 8.09 |
| CHEMBL2047847 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047849 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2047848 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL2047847 | — | IC50 | = | 24.0 | nM | 7.62 |