Assay Detail
Binding
CHEMBL2050843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]glycine from NMDA receptor in rat cortical synaptical membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.85 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 7.10 |
| CHEMBL2047403 | — | — | 1 | 6.10 |
| CHEMBL2047397 | — | — | 1 | 6.07 |
| CHEMBL432748 | — | — | 1 | 5.96 |
| CHEMBL2047398 | — | — | 1 | 5.89 |
| CHEMBL2047404 | — | — | 1 | 5.29 |
| CHEMBL2047399 | — | — | 1 | 5.21 |
| CHEMBL2047401 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2047403 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL2047397 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL432748 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2047398 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2047404 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL2047399 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL2047401 | — | Ki | = | 6500.0 | nM | 5.19 |