Assay Detail
Binding
CHEMBL2051158
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Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.48 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46937 | — | — | 1 | 9.60 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.43 |
| CHEMBL2137046 | — | — | 1 | 9.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46937 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL81 | RALOXIFENE | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL2137046 | — | Ki | = | 0.39 | nM | 9.41 |