Assay Detail
Binding
CHEMBL2051159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]estradiol from ERbeta after 4 hrs by scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.44 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 9.29 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.56 |
| CHEMBL46937 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83 | TAMOXIFEN | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL81 | RALOXIFENE | Ki | = | 2.74 | nM | 8.56 |
| CHEMBL46937 | — | Ki | = | 35.0 | nM | 7.46 |