Assay Detail
Binding
CHEMBL2051215
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Inhibition of human recombinant MMP9 catalytic domain incubated for 20 mins by fluorimetric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural products as a gold mine for selective matrix metalloproteinases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.38 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115727 | — | — | 1 | 8.74 |
| CHEMBL241405 | METHYL ROSMARINATE | — | 1 | 6.21 |
| CHEMBL2048505 | DIMETHYL LITHOSPERMATE | — | 1 | 6.00 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.79 |
| CHEMBL2048506 | — | — | 1 | 5.46 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.25 |
| CHEMBL2048509 | — | — | 1 | 5.00 |
| CHEMBL1532097 | DIHYDRODAPHNODORIN B | — | 1 | 4.99 |
| CHEMBL2048502 | MACRATHOIN F | — | 1 | 4.93 |
| CHEMBL2048504 | — | — | 1 | 4.90 |
| CHEMBL504873 | ISOACTEOSIDE | — | 1 | 4.84 |
| CHEMBL2048511 | — | — | 1 | 4.84 |
| CHEMBL2048507 | DAPHNODORIN F | — | 1 | 4.67 |
| CHEMBL2048508 | — | — | 1 | 4.54 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 4.50 |
| CHEMBL187265 | — | — | 1 | - |
| CHEMBL368347 | (+)-SECOISOLARICIRESINOL | 2.0 | 1 | - |
| CHEMBL2048510 | — | — | 1 | - |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | - |
| CHEMBL2048503 | — | — | 1 | - |
| CHEMBL2048512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115727 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL241405 | METHYL ROSMARINATE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2048505 | DIMETHYL LITHOSPERMATE | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL2048506 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL2048509 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL1532097 | DIHYDRODAPHNODORIN B | IC50 | = | 10170.0 | nM | 4.99 |
| CHEMBL2048502 | MACRATHOIN F | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL2048504 | — | IC50 | = | 12490.0 | nM | 4.90 |
| CHEMBL504873 | ISOACTEOSIDE | IC50 | = | 14280.0 | nM | 4.84 |
| CHEMBL2048511 | — | IC50 | = | 14280.0 | nM | 4.84 |
| CHEMBL2048507 | DAPHNODORIN F | IC50 | = | 21240.0 | nM | 4.67 |
| CHEMBL2048508 | — | IC50 | = | 28790.0 | nM | 4.54 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 32020.0 | nM | 4.50 |
| CHEMBL187265 | — | IC50 | - | — | - | |
| CHEMBL368347 | (+)-SECOISOLARICIRESINOL | IC50 | - | — | - | |
| CHEMBL2048510 | — | IC50 | - | — | - | |
| CHEMBL43065 | OXYRESVERATROL | IC50 | - | — | - | |
| CHEMBL2048503 | — | IC50 | - | — | - | |
| CHEMBL2048512 | — | IC50 | - | — | - |