Assay Detail
Binding
CHEMBL2051271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 50 | 5.36 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047808 | — | — | 1 | 5.91 |
| CHEMBL2047814 | — | — | 1 | 5.86 |
| CHEMBL2047800 | — | — | 1 | 5.68 |
| CHEMBL2047802 | — | — | 1 | 5.63 |
| CHEMBL2047839 | — | — | 1 | 5.61 |
| CHEMBL2047819 | — | — | 1 | 5.61 |
| CHEMBL2047812 | — | — | 1 | 5.61 |
| CHEMBL2047837 | — | — | 1 | 5.60 |
| CHEMBL2047797 | — | — | 1 | 5.55 |
| CHEMBL2047798 | — | — | 1 | 5.54 |
| CHEMBL2047820 | — | — | 1 | 5.53 |
| CHEMBL2047799 | — | — | 1 | 5.52 |
| CHEMBL2047844 | — | — | 1 | 5.52 |
| CHEMBL2047845 | — | — | 1 | 5.51 |
| CHEMBL2047836 | — | — | 1 | 5.51 |
| CHEMBL2047805 | — | — | 1 | 5.50 |
| CHEMBL2047796 | — | — | 1 | 5.49 |
| CHEMBL2047815 | — | — | 1 | 5.49 |
| CHEMBL2047801 | — | — | 1 | 5.48 |
| CHEMBL2047817 | — | — | 1 | 5.48 |
| CHEMBL2047827 | — | — | 1 | 5.48 |
| CHEMBL2047810 | — | — | 1 | 5.46 |
| CHEMBL2047834 | — | — | 1 | 5.46 |
| CHEMBL2047825 | — | — | 1 | 5.46 |
| CHEMBL2047829 | — | — | 1 | 5.44 |
| CHEMBL2047842 | — | — | 1 | 5.42 |
| CHEMBL2047841 | — | — | 1 | 5.37 |
| CHEMBL2047818 | — | — | 1 | 5.37 |
| CHEMBL2047804 | — | — | 1 | 5.36 |
| CHEMBL2047809 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047808 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL2047814 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL2047800 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL2047802 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL2047839 | — | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL2047819 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL2047812 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL2047837 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL2047797 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL2047798 | — | Ki | = | 2870.0 | nM | 5.54 |
| CHEMBL2047820 | — | Ki | = | 2960.0 | nM | 5.53 |
| CHEMBL2047799 | — | Ki | = | 3050.0 | nM | 5.52 |
| CHEMBL2047844 | — | Ki | = | 3010.0 | nM | 5.52 |
| CHEMBL2047836 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL2047845 | — | Ki | = | 3095.0 | nM | 5.51 |
| CHEMBL2047805 | — | Ki | = | 3180.0 | nM | 5.50 |
| CHEMBL2047796 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL2047815 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL2047801 | — | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL2047817 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL2047827 | — | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL2047810 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL2047834 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL2047825 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL2047829 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL2047842 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL2047818 | — | Ki | = | 4320.0 | nM | 5.37 |
| CHEMBL2047841 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL2047804 | — | Ki | = | 4360.0 | nM | 5.36 |
| CHEMBL2047809 | — | Ki | = | 4370.0 | nM | 5.36 |
| CHEMBL2047828 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL2047838 | — | Ki | = | 4530.0 | nM | 5.34 |
| CHEMBL2047824 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL2047803 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL2047807 | — | Ki | = | 5460.0 | nM | 5.26 |
| CHEMBL2047811 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL2047806 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL2047832 | — | Ki | = | 6540.0 | nM | 5.18 |
| CHEMBL2047826 | — | Ki | = | 6640.0 | nM | 5.18 |
| CHEMBL2047831 | — | Ki | = | 7510.0 | nM | 5.12 |
| CHEMBL2047843 | — | Ki | = | 7640.0 | nM | 5.12 |
| CHEMBL2047840 | — | Ki | = | 7650.0 | nM | 5.12 |
| CHEMBL2047821 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL2047830 | — | Ki | = | 8690.0 | nM | 5.06 |
| CHEMBL2047813 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL2047822 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL2047823 | — | Ki | = | 10540.0 | nM | 4.98 |
| CHEMBL2047835 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL2047833 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL2047816 | — | Ki | = | 43000.0 | nM | 4.37 |