Assay Detail
Functional
CHEMBL2059948
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Antiviral activity against Hepatitis C virus genotype 1b infected in human HBI10A cells assessed as inhibition of viral replication in presence of 10% FBS
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | HBI10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 4.74 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236207 | BETA-2'-C-METHYL-7-DEAZA-ADENOSINE | — | 1 | 6.52 |
| CHEMBL2057531 | — | — | 1 | 5.75 |
| CHEMBL2059141 | — | — | 1 | 5.72 |
| CHEMBL2059130 | — | — | 1 | 5.72 |
| CHEMBL2059128 | — | — | 1 | 5.11 |
| CHEMBL2059139 | — | — | 1 | 5.11 |
| CHEMBL2058932 | — | — | 1 | 4.52 |
| CHEMBL2059137 | — | — | 1 | 4.52 |
| CHEMBL2059351 | — | — | 1 | 4.46 |
| CHEMBL2059134 | — | — | 1 | 4.46 |
| CHEMBL2059350 | — | — | 1 | 4.43 |
| CHEMBL2059133 | — | — | 1 | 4.43 |
| CHEMBL2059349 | — | — | 1 | 4.39 |
| CHEMBL2059132 | — | — | 1 | 4.39 |
| CHEMBL2059131 | — | — | 1 | 4.38 |
| CHEMBL2059129 | — | — | 1 | 4.38 |
| CHEMBL2059140 | — | — | 1 | 4.38 |
| CHEMBL2059347 | — | — | 1 | 4.38 |
| CHEMBL2057228 | — | — | 1 | 4.34 |
| CHEMBL2059348 | — | — | 1 | 4.34 |
| CHEMBL2059135 | — | — | 1 | 4.25 |
| CHEMBL2057529 | — | — | 1 | 4.25 |
| CHEMBL2058931 | — | — | 1 | - |
| CHEMBL2057530 | — | — | 1 | - |
| CHEMBL2059138 | — | — | 1 | - |
| CHEMBL2059136 | — | — | 1 | - |
| CHEMBL2058933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236207 | BETA-2'-C-METHYL-7-DEAZA-ADENOSINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2057531 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2059141 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2059130 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2059128 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2059139 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2058932 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2059137 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2059351 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2059134 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2059350 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL2059133 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL2059349 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2059132 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2059131 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2059129 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2059140 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2059347 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2057228 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2059348 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2059135 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL2057529 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL2058931 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2057530 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL2059138 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2059136 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2058933 | — | EC50 | > | 100000.0 | nM | - |