Assay Detail
Functional
CHEMBL2060644
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Inhibition of mouse B-cell splenocyte activation by cell proliferation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Splenocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.39 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916891 | — | — | 1 | 8.47 |
| CHEMBL2057922 | — | — | 1 | 7.50 |
| CHEMBL2057920 | — | — | 1 | 7.25 |
| CHEMBL2057913 | — | — | 1 | 6.89 |
| CHEMBL2057921 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916891 | — | IC50 | = | 3.41 | nM | 8.47 |
| CHEMBL2057922 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2057920 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2057913 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2057921 | — | IC50 | = | 142.0 | nM | 6.85 |