Assay Detail
Binding
CHEMBL2060770
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Binding affinity to biotinylated Escherichia coli FimH-lectin domain after 30 mins by biolayer interferometry method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 8.65 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1170270 | — | — | 1 | 9.85 |
| CHEMBL1171654 | — | — | 1 | 9.31 |
| CHEMBL1170079 | — | — | 1 | 9.00 |
| CHEMBL1172857 | — | — | 1 | 8.94 |
| CHEMBL1171475 | — | — | 1 | 8.90 |
| CHEMBL1170267 | — | — | 1 | 8.81 |
| CHEMBL1171651 | — | — | 1 | 8.70 |
| CHEMBL1172588 | — | — | 1 | 8.66 |
| CHEMBL1169878 | — | — | 1 | 8.58 |
| CHEMBL1172931 | — | — | 1 | 8.56 |
| CHEMBL1173538 | — | — | 1 | 8.56 |
| CHEMBL1170072 | — | — | 1 | 8.52 |
| CHEMBL1172749 | — | — | 1 | 8.46 |
| CHEMBL1171278 | — | — | 1 | 8.40 |
| CHEMBL1171242 | — | — | 1 | 7.84 |
| CHEMBL1170453 | — | — | 1 | 7.36 |
| CHEMBL2058211 | — | — | 1 | - |
| CHEMBL2058210 | — | — | 1 | - |
| CHEMBL1172856 | — | — | 1 | - |
| CHEMBL2058201 | — | — | 1 | - |
| CHEMBL2058202 | — | — | 1 | - |
| CHEMBL1172858 | — | — | 1 | - |
| CHEMBL2058204 | — | — | 1 | - |
| CHEMBL1171277 | — | — | 1 | - |
| CHEMBL1171474 | — | — | 1 | - |
| CHEMBL2058203 | — | — | 1 | - |
| CHEMBL1170269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1170270 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL1171654 | — | Kd | = | 0.49 | nM | 9.31 |
| CHEMBL1170079 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL1172857 | — | Kd | = | 1.14 | nM | 8.94 |
| CHEMBL1171475 | — | Kd | = | 1.25 | nM | 8.90 |
| CHEMBL1170267 | — | Kd | = | 1.56 | nM | 8.81 |
| CHEMBL1171651 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL1172588 | — | Kd | = | 2.21 | nM | 8.66 |
| CHEMBL1169878 | — | Kd | = | 2.61 | nM | 8.58 |
| CHEMBL1172931 | — | Kd | = | 2.72 | nM | 8.56 |
| CHEMBL1173538 | — | Kd | = | 2.72 | nM | 8.56 |
| CHEMBL1170072 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL1172749 | — | Kd | = | 3.45 | nM | 8.46 |
| CHEMBL1171278 | — | Kd | = | 3.99 | nM | 8.40 |
| CHEMBL1171242 | — | Kd | = | 14.5 | nM | 7.84 |
| CHEMBL1170453 | — | Kd | = | 43.66 | nM | 7.36 |
| CHEMBL2058211 | — | Kd | - | — | - | |
| CHEMBL2058210 | — | Kd | - | — | - | |
| CHEMBL1172856 | — | Kd | = | 0.001 | nM | - |
| CHEMBL2058201 | — | Kd | - | — | - | |
| CHEMBL2058202 | — | Kd | - | — | - | |
| CHEMBL1172858 | — | Kd | - | — | - | |
| CHEMBL2058204 | — | Kd | - | — | - | |
| CHEMBL1171277 | — | Kd | = | 0.008 | nM | - |
| CHEMBL1171474 | — | Kd | - | — | - | |
| CHEMBL2058203 | — | Kd | - | — | - | |
| CHEMBL1170269 | — | Kd | - | — | - |