Assay Detail
Binding
CHEMBL2060771
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Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C3H 10T1/2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.66 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2059867 | — | — | 1 | 8.15 |
| CHEMBL2057336 | — | — | 1 | 8.10 |
| CHEMBL2059870 | — | — | 1 | 8.10 |
| CHEMBL2059862 | — | — | 1 | 7.96 |
| CHEMBL2059865 | — | — | 1 | 7.89 |
| CHEMBL2059864 | — | — | 1 | 7.82 |
| CHEMBL2059875 | — | — | 1 | 7.77 |
| CHEMBL2059861 | — | — | 1 | 7.75 |
| CHEMBL2059868 | — | — | 1 | 7.68 |
| CHEMBL2059863 | — | — | 1 | 7.66 |
| CHEMBL2059869 | — | — | 1 | 7.57 |
| CHEMBL2059873 | — | — | 1 | 7.55 |
| CHEMBL2059871 | — | — | 1 | 7.54 |
| CHEMBL2059859 | — | — | 1 | 7.52 |
| CHEMBL2059860 | — | — | 1 | 7.41 |
| CHEMBL2059876 | — | — | 1 | 7.40 |
| CHEMBL2059866 | — | — | 1 | 7.05 |
| CHEMBL2057337 | — | — | 1 | 6.94 |
| CHEMBL2059874 | — | — | 1 | - |
| CHEMBL2059872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2059867 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2057336 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2059870 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2059862 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2059865 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2059864 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2059875 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2059861 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2059868 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2059863 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2059869 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2059873 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2059871 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2059859 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2059860 | — | EC50 | = | 39.2 | nM | 7.41 |
| CHEMBL2059876 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2059866 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2057337 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2059874 | — | EC50 | - | — | - | |
| CHEMBL2059872 | — | EC50 | > | 145.0 | nM | - |