Assay Detail
Binding
CHEMBL2060772
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Inhibition of p38alpha
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.25 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183630 | — | — | 1 | 7.77 |
| CHEMBL184712 | — | — | 1 | 7.60 |
| CHEMBL184721 | — | — | 1 | 7.52 |
| CHEMBL366255 | — | — | 1 | 7.29 |
| CHEMBL365472 | — | — | 1 | 6.78 |
| CHEMBL2059860 | — | — | 1 | 5.80 |
| CHEMBL2059865 | — | — | 1 | 5.57 |
| CHEMBL2057337 | — | — | 1 | 5.46 |
| CHEMBL2059864 | — | — | 1 | 5.23 |
| CHEMBL2059863 | — | — | 1 | 4.92 |
| CHEMBL2059873 | — | — | 1 | 4.85 |
| CHEMBL2059875 | — | — | 1 | 4.82 |
| CHEMBL2057336 | — | — | 1 | 4.82 |
| CHEMBL2059861 | — | — | 1 | 4.82 |
| CHEMBL2059866 | — | — | 1 | 4.72 |
| CHEMBL2059876 | — | — | 1 | 4.66 |
| CHEMBL2059872 | — | — | 1 | 4.52 |
| CHEMBL2059859 | — | — | 1 | 4.52 |
| CHEMBL2059867 | — | — | 1 | 4.44 |
| CHEMBL2059862 | — | — | 1 | 4.00 |
| CHEMBL2059868 | — | — | 1 | 4.00 |
| CHEMBL2059869 | — | — | 1 | 4.00 |
| CHEMBL2059870 | — | — | 1 | 4.00 |
| CHEMBL2059871 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183630 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL184712 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL184721 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL366255 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL365472 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL2059860 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2059865 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2057337 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2059864 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2059863 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2059873 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2059875 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2057336 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2059861 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2059866 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2059876 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2059872 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2059859 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2059867 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2059862 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2059868 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2059869 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2059870 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2059871 | — | IC50 | = | 100000.0 | nM | 4.00 |