Assay Detail
Binding
CHEMBL2060903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in mouse cerebellum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.97 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2057693 | — | — | 1 | 9.37 |
| CHEMBL483566 | — | — | 1 | 9.29 |
| CHEMBL490665 | NALFURAFINE HYDROCHLORIDE | 4.0 | 1 | 9.23 |
| CHEMBL2057692 | — | — | 1 | 7.61 |
| CHEMBL2057691 | — | — | 1 | 7.08 |
| CHEMBL485583 | — | — | 1 | 6.77 |
| CHEMBL2057689 | — | — | 1 | 6.41 |
| CHEMBL2057688 | — | — | 1 | - |
| CHEMBL2057690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2057693 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL483566 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL490665 | NALFURAFINE HYDROCHLORIDE | Ki | = | 0.582 | nM | 9.23 |
| CHEMBL2057692 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL2057691 | — | Ki | = | 83.2 | nM | 7.08 |
| CHEMBL485583 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL2057689 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL2057688 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2057690 | — | Ki | > | 1000.0 | nM | - |