Assay Detail
Functional
CHEMBL2060975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D₁ receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.77 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286080 | SKF-38393 | — | 1 | 6.77 |
| CHEMBL2057445 | — | — | 1 | - |
| CHEMBL2057446 | — | — | 1 | - |
| CHEMBL2057455 | — | — | 1 | - |
| CHEMBL62 | SCH-23390 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286080 | SKF-38393 | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2057445 | — | EC50 | - | — | - | |
| CHEMBL2057446 | — | EC50 | - | — | - | |
| CHEMBL2057455 | — | EC50 | - | — | - | |
| CHEMBL62 | SCH-23390 | EC50 | - | — | - |