Assay Detail
Functional
CHEMBL2061045
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Antibacterial activity against Escherichia coli K-12 ATCC 25404 assessed as inhibition of biofilm formation after 2 hrs by confocal laser microscopic analysis
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.53 | 7.37 |
| MED | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2058203 | — | — | 1 | 7.37 |
| CHEMBL2058204 | — | — | 1 | 7.14 |
| CHEMBL2058202 | — | — | 1 | 6.89 |
| CHEMBL2058201 | — | — | 1 | 6.80 |
| CHEMBL2058197 | — | — | 1 | 6.77 |
| CHEMBL2058195 | — | — | 1 | 6.58 |
| CHEMBL2058196 | — | — | 1 | 6.48 |
| CHEMBL2058200 | — | — | 1 | 6.28 |
| CHEMBL1170270 | — | — | 2 | 6.13 |
| CHEMBL2058198 | — | — | 1 | 6.05 |
| CHEMBL1171277 | — | — | 1 | 6.03 |
| CHEMBL1172856 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2058203 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2058204 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2058202 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2058201 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2058197 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2058195 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2058196 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2058200 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1170270 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL2058198 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1171277 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1172856 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1170270 | — | MED | > | 0.74 | uM | - |