Assay Detail
Functional
CHEMBL2061925
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Agonist activity at 5HT4 receptor in guinea pig colon assessed as longitudinal muscle plexus contraction
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Colon |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.07 | 8.20 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76370 | TEGASEROD | 4.0 | 1 | 8.20 |
| CHEMBL2059590 | — | — | 2 | 8.00 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76370 | TEGASEROD | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL2059590 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL39 | SEROTONIN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2059590 | — | Activity | - | — | - |