Assay Detail
Binding
CHEMBL2061970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT₁ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.72 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2058860 | — | — | 1 | 9.05 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 9.00 |
| CHEMBL2058859 | — | — | 1 | 8.89 |
| CHEMBL2058861 | — | — | 1 | 8.59 |
| CHEMBL2058864 | — | — | 1 | 8.43 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.79 |
| CHEMBL2058855 | — | — | 1 | 7.71 |
| CHEMBL2058862 | — | — | 1 | 7.65 |
| CHEMBL2058865 | — | — | 1 | 7.42 |
| CHEMBL2058856 | — | — | 1 | 7.11 |
| CHEMBL2058863 | — | — | 1 | 7.11 |
| CHEMBL2058858 | — | — | 1 | 7.01 |
| CHEMBL2058857 | — | — | 1 | 6.93 |
| CHEMBL2058866 | — | — | 1 | 6.68 |
| CHEMBL2058588 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2058860 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1017 | TELMISARTAN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2058859 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2058861 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2058864 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL191 | LOSARTAN | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL2058855 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL2058862 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL2058865 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL2058856 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL2058863 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2058858 | — | IC50 | = | 96.8 | nM | 7.01 |
| CHEMBL2058857 | — | IC50 | = | 118.5 | nM | 6.93 |
| CHEMBL2058866 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL2058588 | — | IC50 | = | 410.0 | nM | 6.39 |