Compound Detail
CHEMBL2058861
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CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
Basic Information
| ChEMBL ID | CHEMBL2058861 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GZAWCWVPZBVPIK-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
585.7
MW (Da)
6.17
ALogP
7
HBA
2
HBD
110.6
PSA (Ų)
0.19
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.59
Kd 1 meas. best 7.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor CHEMBL227 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
| Type-1 angiotensin II receptor CHEMBL3948 | Kd | 7.83 | 7.83 | 14.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | IC50 | = | 2.6 | nM | 8.59 | Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins... | 22727371 |
| Type-1 angiotensin II receptor | Kd | = | 14.79 | nM | 7.83 | Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta asse... | 22727371 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22727371 | 10.1016/j.bmc.2012.05.056 | Type-1 angiotensin II receptor | 2 |
| 22727371 | 10.1016/j.bmc.2012.05.056 | Photobacterium phosphoreum | 1 |
Data from ChEMBL 36 via Core Engine