Assay Detail
Binding
CHEMBL2065221
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Inhibition of PI3Kbeta by high throughput chemoproteomics binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.92 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064571 | — | — | 1 | 5.90 |
| CHEMBL2064479 | — | — | 1 | 4.70 |
| CHEMBL2064514 | — | — | 1 | 4.70 |
| CHEMBL2064570 | — | — | 1 | 4.70 |
| CHEMBL2064567 | — | — | 1 | 4.60 |
| CHEMBL2064478 | — | — | 1 | - |
| CHEMBL2064566 | — | — | 1 | - |
| CHEMBL2064569 | — | — | 1 | - |
| CHEMBL2064572 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064571 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2064479 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2064514 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2064570 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2064567 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL2064478 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2064566 | — | IC50 | = | 199526.23 | nM | - |
| CHEMBL2064569 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2064572 | — | IC50 | > | 100000.0 | nM | - |