Assay Detail
Functional
CHEMBL2065299
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Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of benzo-annulated tryptanthrins and their biological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.03 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.55 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.75 |
| CHEMBL2064576 | — | — | 1 | 5.21 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 5.07 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.00 |
| CHEMBL2064578 | — | — | 1 | 4.90 |
| CHEMBL2064579 | — | — | 1 | 4.62 |
| CHEMBL2064574 | — | — | 1 | 4.61 |
| CHEMBL2064573 | BENZO[K]TRYPTANTHRIN | — | 1 | 4.59 |
| CHEMBL2064577 | — | — | 1 | 4.58 |
| CHEMBL2064575 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL2064576 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL2064578 | — | IC50 | = | 12630.0 | nM | 4.90 |
| CHEMBL2064579 | — | IC50 | = | 23960.0 | nM | 4.62 |
| CHEMBL2064574 | — | IC50 | = | 24690.0 | nM | 4.61 |
| CHEMBL2064573 | BENZO[K]TRYPTANTHRIN | IC50 | = | 25760.0 | nM | 4.59 |
| CHEMBL2064577 | — | IC50 | = | 26210.0 | nM | 4.58 |
| CHEMBL2064575 | — | IC50 | = | 32780.0 | nM | 4.48 |