Assay Detail
Binding
CHEMBL2065327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DTG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vesicular acetylcholine transporter (CHEMBL2125) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.72 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064617 | — | — | 1 | 7.87 |
| CHEMBL2064616 | — | — | 1 | 7.86 |
| CHEMBL2064615 | — | — | 1 | 7.69 |
| CHEMBL20943 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064617 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL2064616 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL2064615 | — | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL20943 | — | Ki | = | 33.9 | nM | 7.47 |